SARS-CoV-1 and -2 – Communicable Diseases Research

An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

Article

Published on 2022-09-222022-11-15
Journal: PLoS Pathogens
[Category] SARS, 진단,

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

SARS-CoV-2 베타에 대한 항체 반응은 다른 변이체와의 항원 거리를 강조합니다

Article

Published on 2022-01-122022-09-10
Journal: Cell Host & Microbe
[Category] MERS, SARS, 변종, 진단,

[키워드] Abstract Alter Analysis antibody Antibody Response antigenic antigenic structure Beta Beta variant binding conserved COVID-19 Delta E484K epitope escape Express immune responses include individual infected with SARS-CoV-2 K417N mAb mAbs multiple mutation multiple mutations mutated Mutation N-terminal domain N501Y neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody NTD other variant pandemic Patient performed RBD Receptor-binding domain Recognition recognize residue residues SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 strain separated sequence serum Spike protein Structure structure-function the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine Vaccine-induced immunity variant variants of SARS-CoV-2 viruses
[DOI] 10.1016/j.chom.2021.11.013 PMC 바로가기 [Article Type] Article

Computer-aided screening for potential TMPRSS2 inhibitors: a combination of pharmacophore modeling, molecular docking and molecular dynamics simulation approaches

잠재적인 TMPRSS2 억제제에 대한 컴퓨터 지원 스크리닝: 약전 모델링, 분자 도킹 및 분자 역학 시뮬레이션 접근법의 조합

Article

Published on 2021-09-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] 치료제,

[키워드] active site active sites acute respiratory syndrome ADME analyses approach approaches binding binding affinities binding affinity Chemistry Combination Compound compounds coronavirus COVID-19 docked docking scores drug drugs facilitate feature free energy homology homology modeling Host host cells host protein host proteins identify inhibit inhibitors Interaction molecular docking molecular dynamics Molecular dynamics simulation pharmacophore pharmacophore modeling proliferation residue retrieved SARS-CoV-1 and -2 Serine serine protease serine protease. stability target tested these compound these compounds TMPRSS2 trajectory transmembrane serine protease virus was used Zinc ZINC database
[DOI] 10.1080/07391102.2020.1792346 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling

Article

Published on 2021-07-172022-10-31
Journal: Cells
[Category] COVID-19, SARS,

[키워드] ACE2 ACE2 internalization acute respiratory syndrome angiotensin-converting enzyme 2 BHK21 bind binding bioinformatics Cell cells cellular Clathrin-mediated endocytosis conserved coronavirus coronavirus entry CoV cytoplasmic cytoplasmic tail deleted demonstrated Dipeptidyl peptidase 4 domain eight Endosomal acidification HEK293T Host host cell host cells independent of Infection inhibited inhibitor motif pathway phosphorylation sites pseudotyped RBD receptor SARS-CoV SARS-CoV antibody SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Signaling significantly spike glycoprotein Spike protein Transmission Treatment understanding viral pathogenesis virus infection
[DOI] 10.3390/cells10071814 PMC 바로가기 [Article Type] Article

The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer

암에서 SARS-CoV-2와 티로신 키나제 수용체 신호 전달 간의 간섭

Review

Published on 2021-05-022022-09-10
Journal: International Journal of Molecular Sciences
[Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] accelerate activated addition approach Cancer cancer cell Cancer cells cell proliferation Characteristics clinically coronavirus coronavirus correlation COVID-19 Critical diagnosed division downstream downstream signaling pathways drug Drug repurposing dysregulation dysregulations EGFR help identify infection rate information interact interfere Interference Invasion kinase management mechanism MERS metabolism pandemic pathogen Pathways Patient phenotypic produced receptor repurposing required Research research and development resource SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Scientific community signaling pathway signaling pathways strongly related Structure therapeutic agent therapeutic agents Therapeutic compounds treat Treatment tyrosine tyrosine kinase tyrosine kinase receptor Viral viral infection Viral vector virus viruses
[DOI] 10.3390/ijms22094830 PMC 바로가기 [Article Type] Review

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다

Research Article

Published on 2021-04-092022-09-10
Journal: PLoS Pathogens
[Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type
[DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article

An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity

Review

Published on 2021-03-262022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

[키워드] acute respiratory distress Administered Anti-viral ARDS China common cold-like symptoms convalescent plasma coronavirus coronavirus Coronaviruses CoV COVID-19 vaccine current death deaths develop disease effective Epidemiology evade Guangdong Host human coronavirus Hydroxychloroquine immune response immune responses Immunosuppressive treatment individual infecting Infection Innate Innate immunity interface MERS-CoV Middle East Mild modulate mortality rate MOST Pathogenesis Phylogeny pro-inflammatory produced Remdesivir Research respiratory respiratory tract RNA viruses SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Saudi Arabia severity spread to syndrome target therapeutic intervention therapy Transmission Treatment type I interferon viral life cycle viral structure viruses zoonotic
[DOI] 10.3390/v13040560 PMC 바로가기 [Article Type] Review

The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

Cellular Response to Infection

Published on 2021-02-092022-10-30
Journal: Journal of Virology
[Category] COVID-19, SARS,

[키워드] Activation Antiviral antiviral activity cathepsin Cell cellular entry cleavage cleavage site consequence coronavirus COVID-19 entry of SARS-CoV-2 exacerbated expression furin cleavage furin cleavage site furin-like protease glycoprotein IFITM IFITM2 IFITM3 individuals inhibit inhibited innate immune Innate immunity interferons (IFNs late endosomes maturation membrane protein mitigate polybasic potential therapeutic target precursor producer cell promote protease Protein reduce reduce viral replication Replication restrict S1/S2 boundary SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 replication SARS-CoV-2 spike sensitivity Site spike suggested the spike protein therapeutic strategy transmembrane Transmissibility transmissibility of SARS-CoV-2 Transmission Treatment Type type 1 interferon type I type I IFNs type I interferon type II IFN viral entry viral spike viruses
[DOI] 10.1128/JVI.02422-20 PMC 바로가기 [Article Type] Cellular Response to Infection

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

SARS-CoV-2 스파이크 단백질의 다량체화 및 글리코실화 의존성 수용체 결합

Research Article

Published on 2021-02-082022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, COVID-19,

[키워드] ACE2 expression adherent Author benefit binding binding affinity bronchiolar duct bronchiolar ducts candidate cell line cell lines cells complex complex glycosylated protein COVID19 demonstrated determine domain domains fluorescent fluorescent multimeric RBD proteins glycosylated glycosylated RBD glycosylation GnTI-/- mutant cells HEK293T increase mannose mannose glycosylation MONITOR monomeric monomeric and trimeric fluorescent RBD proteins mutant cells native viruses pandemic profile profiles Protein RBD RBD protein RBD proteins Receptor binding recombinant spike proteins respiratory respiratory tissue respiratory tissues sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike protein Spike proteins these viruses tissues toolkit trimer trimeric trimeric fully glycosylated RBD trimers trimeric RBD protein variants virus viruses were stained zoonotic
[DOI] 10.1371/journal.ppat.1009282 PMC 바로가기 [Article Type] Research Article

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens
[Category] COVID-19, Medicine and Health Sciences,

[키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection
[DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article